TITLE:
Neutrophil Lymphocyte Ratio as an Inflammatory Marker in Chronic Kidney Disease: Determinants and Correlates
AUTHORS:
Peter Kehinde Uduagbamen, Adesola Temitope Oyelese, Abdallah Olukayode AdebolaYusuf, Mary Umoh Thompson, Boladale Ajani Afeez Alalade, Osaze Ehioghae
KEYWORDS:
Neutrophil Lymphocyte Ratio, Inflammation, Chronic Kidney Disease, Platelet Lymphocyte Ratio, Hyperuricemia, Albuminuria
JOURNAL NAME:
Open Journal of Nephrology,
Vol.12 No.1,
January
18,
2022
ABSTRACT: Introduction: Inflammation has been implicated as a major reason for the higher morbidity and mortality in chronic kidney disease (CKD) compared to the diseases that commonly precedes it. The neutrophil lymphocyte ratio (NLR) has increasingly been reported to be a marker of systemic inflammation. We studied the neutrophil lymphocyte ratio and its relationship with kidney function and other markers of inflammation in health and in CKD. Methods: Two hundred and forty four participants in three cohorts: healthy, CKD stage 1 - 2 and, stage 3 - 4, were studied. Data of clinical, NLR, uric acid, urine albumin creatinine ratio (UACR), electrolytes were documented and independent associates of NLR were determined. Results: The NLR was higher in the CKD cohorts, P Conclusion: The NLR as an inflammatory marker is elevated in chronic kidney disease, and increases with disease severity hence it can be a useful tool in determining the presence and severity of inflammation in CKD.