TITLE:
The Effect of Different Surgical Methods on the Number of Circulating Tumor Cells in the Peripheral Blood of Patients with Renal Cell Carcinoma
AUTHORS:
Dianbin Song, Zhiyong Wang, Xiuming Li, Jingjing Zhang, Qiang Chi, Hui Xu, Hongyang Li, Ying Liu
KEYWORDS:
Retroperitoneal Laparoscopic Radical Nephrectomy, Open Radical Nephrectomy, Number of Circulating Tumor Cells
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.13 No.1,
January
11,
2022
ABSTRACT: Objective: The objective is to explore the effects of different surgical
methods-retroperitoneal laparoscopic radical
nephrectomy (RLRN) and open radical nephrectomy
(ORN) on the number of circulating tumor cells (CTC) in the peripheral blood of
patients with renal cancer. Methods: The clinical data of 63
patients in the Department of Urology, Affiliated Hospital of Chengde Medical
College who underwent radical surgery for renal cancer were divided into CTC
positive group (18 cases of open surgery and 16 cases of minimally invasive
surgery) and CTC negative group (14 cases of open surgery), 15 cases of
minimally invasive surgery), overall group (32 cases of open surgery, 31 cases
of minimally invasive surgery). Observe the changes in the number of CTC 1 week
before operation and 1 week after operation. Results: In the positive
group, whether it was open surgery or minimally invasive surgery, the
postoperative CTC level of patients was significantly reduced (P surgery (P 0.05). In the overall group, both open and minimally invasive
surgery CTC decreased significantly, and the difference was statistically
significant (P Conclusion: The two different surgical
methods can reduce the level of CTC, but compared with ORN, RLRN can
significantly increase the number of postoperative CTC. Patients in the
CTC-negative group may be less suitable for minimally invasive surgery. CTC
levels have certain potential in the selection and guidance of treatment modes
for patients with renal cell carcinoma (RCC).