TITLE:
Role of CD4+ and CD8+ T Lymphocyte in the Onset of Stroke in People Living with HIV in Pointe-Noire
AUTHORS:
Prince Eliot Galieni Sounga Bandzouzi, Ghislain Armel Mpandzou, Josué Euberma Diatewa, Dina Happia Motoula-Latou, Charles Godefroy Koubemba, Paul Macaire Ossou-Nguiet, Donatien Moukassa
KEYWORDS:
CD4+, CD8+ T Lymphocytes, HIV, Stroke, Pointe-Noire
JOURNAL NAME:
World Journal of Neuroscience,
Vol.12 No.1,
January
4,
2022
ABSTRACT: Objective: To determine the role of CD4+ and CD8+ T
lymphocytes in the onset of stroke in people living with HIV. Methodology: This was a descriptive, cross-sectional study from January to July 2019, in the
neurology department of loandjili general hospital, including any patient
hospitalized for a first episode of stroke confirmed by brain scan. The study
variables were: age, sex, CRP value, serum T cell CD4+, CD8+. The statistical
analysis was carried out using the EPI info 7 software. Results: Twenty
stroke patients were included. The relative frequency of HIV was 20%. The risk
factors were potentiated by immunosuppression
of CD4+ T cells. Sixty percent (60%) of the patients had a CD4+ count 3 and the mean CD4+ count was ±191/mm3. Stroke was the predominant mechanism of injury with
a frequency of 70%, the only injury mechanism of stroke in patients with
CD8+ T cell count > 800/mm3 (p = 0.04). Conclusion: Risk factors
are potentiated by TCD4+ lymphocyte immunosupression, also CD8+ lymphocytes of
immune system activation marker are a cardiovascular
risk factor for living people with HIV.