TITLE:
Research Progress on the Role of miRNA-448 in Tumor
AUTHORS:
Changliang Jiao, Cheng Yang, Xingjun Tan, Min Guo, Xiaoxin Gao, Juncheng Guo
KEYWORDS:
miRNA, The miRNA-448, Tumor, The Research Progress
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.12 No.12,
December
30,
2021
ABSTRACT: MicroRNA
(miRNA) is a class of endogenous non-coding and regulatory single stranded
small RNA molecules, about 18 - 24 nucleotides in length. More than 800 miRNA coding genes have been
identified in the human genome, and about 113 target genes are predicted to be
regulated, which distinguishes it from most oligonucleotides and functional RNA
degraded fragments. It is involved in the regulation of cell proliferation,
differentiation, apoptosis and other cell activities. At the same time, it is
abnormal in liver cancer, breast cancer, glioma and other tumors, becoming a
new biomarker, and participating in cancer differentiation, invasion and
metastasis through the interaction with multiple target genes, such as SATB1,
NF-KB and 5-HT2B. Mir-448 is abnormally expressed in a variety of tumor cells,
such as liver cancer and non-small cell lung cancer. mirNA-448 may play a very
important role in tumors. In order to deepen the understanding of the role of
mirNA-448 in tumors, this paper reviews the research progress of the role of
mirNA-448 in tumors.