Article citationsMore>>

Schmitt-Hoffmann, A., Roos, B., Heep, M., et al. (2006) Single-Ascending-Dose Pharmacokinetics and Safety of the Novel Broad-Spectrum Antifungal Triazole BAL4815 after Intravenous Infusions (50, 100, and 200 Milligrams) and Oral Administrations (100, 200, and 400 Milligrams) of Its Prodrug, BAL8557, in Healthy Volunteers. Antimicrobial Agents and Chemotherapy, 50, 279-285.
https://doi.org/10.1128/AAC.50.1.279-285.2006

has been cited by the following article:

• TITLE: Monte Carlo Analysis of Different Administration Regiments for Isavuconazole against Candida spp. and Aspergillus spp.

  AUTHORS: Jiuli Hu, Chanchan Hu, Xiaoqin Zhu

  KEYWORDS: Monte Carlo Simulation (MSC), Isavuconazole, Candida spp., Aspergillus spp.

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.12 No.12, December 24, 2021

  ABSTRACT: In our study, we aimed to optimize the dosage regimen of Isavuconazole against Candida spp. and Aspergillus spp. by Monte Carlo simulation (MSC). Pharmacokinetic parameters and microbiological data of Isavuconazole were collected. Then we used MSC to simulate 10,000 patients analyzed by Crystal Ball to calculate probability of target attainment (PTA) and cumulative fraction of response (CFR). With dosages of 100 mg, 200 mg, and 400 mg in oral group and dosages of 100 mg, and 200 mg in intravenous administration, all have different degrees of antifungal effect. But when the dosage regimen was 50 mg IV, the therapeutic effect of Isavuconazole against Aspergillus spp. and Candida spp. were not good.