TITLE:
Early Management of Nephroblastoma: A Single-Center Study in a Sub-Saharan African Country
AUTHORS:
Abdoul Karim Doumbia, Pierre Togo, Mariam Maiga, Mohamed Elmouloud Cissé, Guédiouma Dembélé, Oumar Coulibaly, Karamoko Sacko, Belco Maiga, Djeneba Konaté, Abdou Diarra, Yakaria Coulibaly, Fatoumata Léonie Diakité, Abdoul Aziz Diakité, Boubacar Togo, Check Bougadary Traore, Adama Bah
KEYWORDS:
Cancer, Child, Nephroblastoma, Diagnosis, Prognosis, Mali
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.11 No.4,
December
22,
2021
ABSTRACT: Introduction: Nephroblastoma is the most common renal cancer in pediatrics. The aim of
this study was to describe the epidemiological, clinical, histological
characteristics and the immediate outcome of patients with nephroblastoma. Methodology: This was a cross-sectional study of 18 cases of unilateral nephroblastoma,
carried out in the pediatric oncology unit (UOP) of the CHU Gabriel Touré from
January 2015 to December 2016. Results: The mean age of the patients was
33 months old. The sex ratio was 0.63. The average consultation time was 3
months. A case of malformation syndrome (aniridia and mental retardation) had
been observed. The main reason for consultation was abdominal mass (100%)
associated with deterioration of general condition (44%), pain (44%) and fever
(17%). Stage I accounted for 61% and stage II 39%. The postoperative
histological classification made it possible to
find the high-risk blastematous type (33%), the regressive type of intermediate
risk (11%) and the stromal type of intermediate risk (45%). Toxicities
(haematological and digestive) were minimal. The 3-year overall survival was
90%. Conclusion: This study is characterized by the predominance of
stages I and II and the fairly large percentage of histology at intermediate
risk. These results are above all the result of multidisciplinary
collaboration.