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Zhang, M., Di, X., Xu, L., Xu, J., Yang, Y., Jiang, N., Song, L. and Xu, X. (2014) Pharmacokinetics and Pharmacodynamics of Febuxostat under Fasting Conditions in Healthy Individuals. Experimental and Therapeutic Medicine, 7, 393-396.
https://doi.org/10.3892/etm.2013.1414

has been cited by the following article:

• TITLE: Green UHPLC Method for Simultaneous Determination of Febuxostat and Diclofenac in Pharmaceutical Dosage Form and Human Plasma

  AUTHORS: Shimaa A. Mahmoud, Amira M. El-Kosasy, Fatma A. Fouad

  KEYWORDS: Febuxostat, Diclofenac, Ultra-High-Performance Liquid Chromatography, Eco-Scale, Green Analytical Procedure Index Tools

  JOURNAL NAME: Journal of Analytical Sciences, Methods and Instrumentation, Vol.11 No.4, December 20, 2021

  ABSTRACT: Eco-friendly Ultra-high-performance liquid chromatography (UHPLC) with green aqueous-organic mobile phase was applied for the simultaneous determination of febuxostat (FEB) and diclofenac (DIC) with the composition of water:ethanol (85:15 v/v) utilizing phenomenex Kinetex C18 column (4.6 × 100 mm 2.6 μm), flow rate 1 ml/min and UV detection at 280 nm with linear ranges of 0.4 - 4.0 μg/mL and 0.5 - 5.0 μg/mL for FEB and DIC, respectively. The proposed method was also successfully applied to analyze the two drugs in pharmaceutical dosage form and human plasma. The results obtained were validated and statistically analyzed and found to be in accordance with those given by reported methods. Moreover, the greenness of the developed method is assessed using suitable analytical Eco-Scale and GAPI tools and comparison with the previously published methods have been carried out to indicate the priority of the proposed method. UHPLC is considered eco-friendly method regarding uses of safe solvents, simple, accurate and short time of analysis.