TITLE:
Efficacy and Tolerability of Thermocoagulation Treatment of High-Grade Cervical Intraepithelial Neoplasia
AUTHORS:
Beatriz Maykot Kuerten, Paulo Sérgio Viero Naud, Francisco Jose Cidral-Filho, Armando José D’Acampora
KEYWORDS:
Cervical Intraepithelial Neoplasia, Thermocoagulation, Efficacy Results, Ablation Procedures, Cancer Prevention
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.11 No.12,
December
17,
2021
ABSTRACT: Purpose: Cervical cancer is still one of the main causes of cancer and mortality
in women, especially in low- and middle-income countries, although it is a
completely preventable disease through the detection and treatment of
pre-cancer lesions. We
evaluated the efficacy and tolerability of thermocoagulation treatment of
high-grade cervical intraepithelial neoplasia (CIN 2 and 3). Methods: We
evaluated 115 women with high-grade cervical intraepithelial neoplasia, 54 with
CIN 2 and 61 with CIN 3, confirmed by biopsy and without previous treatment,
from January 2016 to December 2018, undergoing thermocoagulation treatment at
the Lower Genital Tract Pathology and Colposcopy Service of the Hospital de
Clinicas de Porto Alegre, Porto Alegre, Brazil. Results: The mean age
was 33.11 years (SD = 9.83) for CIN 2 and 35.28
years (SD = 7.97) for CIN 3 patients.
Treatment efficacy was 90.8% in CIN 2 and 94.9% in CIN 3 cases. Pain was the
main symptom reported at the time of treatment, occurring more frequently in
the CIN 3 group (49.1% versus 27.8% in the CIN 2 group). As the more important
long-term complication, there were 3 cases of pelvic inflammatory disease in
CIN 2 (5.6%) and 3 in CIN 3 group (5.0%). The percentage of residual lesion was
very low in both groups, 5 in CIN 2 group (9.2%) and 2 in CIN 3 group (3.4%). Conclusion: Thermocoagulation is an effective method for the treatment of cervical pre-cancer lesions (CIN 2 and
CIN 3), with a low risk of adverse events and complications.