TITLE:
Polyphenol-Rich Olive Mill Wastewater Extract and Its Potential Use in Hair Care Products
AUTHORS:
Lisa-Marie Sittek, Thomas M. Schmidts, Peggy Schlupp
KEYWORDS:
Hair Growth, Hair Loss, Human Follicle Dermal Papilla Cells, Caffeine, Dihydrotestosterone, IGF-1, VEGF, Reactive Oxygen Species
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.11 No.4,
December
16,
2021
ABSTRACT: In this work, the influence of phenol-enriched olive mill wastewater (OMWW) extract on hair growth was investigated in vitro on human follicle dermal papilla cells. OMWW has already shown great potential for use in skincare products, and its high polyphenol content is predestined to have a positive effect on hair growth. The studies included caffeine, a positive modulator of hair growth, and dihydrotestosterone, which causes hair loss in vivo, as controls. The impact of the investigated compounds on hair growth was evaluated by studies on cell viability and proliferation, the release of growth factors (insulin-like growth factor-1 and vascular endothelial growth factor), and the reduction of reactive oxygen species formation. OMWW showed a positive influence on the proliferation of the human follicle dermal papilla cells. Moreover, the extract leads to a significantly increased secretion of insulin-like growth factor-1, and a considerable reduction in reactive oxygen species formation was observed. Overall, our results show that the investigated phenol-enriched OMWW extract is a promising ingredient for hair care to improve hair growth, prevent hair loss due to oxidative stress and maintain a healthy scalp.