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Moore, K.N., Secord, A.A., Geller, M.A., Miller, D.S., Cloven, N., Fleming, G.F., Wahner Hendrickson, A.E., Azodi, M., Di Silvestro, P., Oza, A.M., Cristea, M., Berek, J.S., Chan, J.K., Rimel, B.J., Matei, D.E., Li, Y., Sun, K., Luptakova, K., Matulonis, U.A. and Monk, B.J. (2019) Niraparib Monotherapy for Late-Line Treatment of Ovarian Cancer (QUADRA): A Multicentre, Open-Label, Single-Arm, Phase 2 Trial. Lancet Oncology, 20, 636-648.
https://doi.org/10.1016/S1470-2045(19)30029-4

has been cited by the following article:

• TITLE: Primary Serous Cystadenocarcinoma of Broad Ligament: A Case Report with Laparoscopic, Histopathologic and Immunohistochemical Findings

  AUTHORS: Kenji Niwa, Motoki Takenaka, Takeaki Saitake, Tiger Koike, Kentaro Nagata, Kentaro Niwa, Kohjiro Niwa, Sakae Mori, Keigo Kuwabara, Akane Onogi, Takuji Tanaka

  KEYWORDS: Primary Broad Ligament Cancer, Serous Cystadenocarcinoma, Immunohistochemistry, Mullerian Tumor

  JOURNAL NAME: Open Journal of Pathology, Vol.12 No.1, December 13, 2021

  ABSTRACT: An 86-year-old Japanese woman underwent an examining laparoscopy for removing the huge pelvic tumor. At laparoscope examination, the cystic tumor was found within the left broad ligament, while the ovaries, fallopian tubes and uterus showed almost normal appearance. The tumor was removed together by total laparoscopic hysterectomy and bilateral salpingo-oophorectomies after the suction of serous content in the broad ligament. Cytological findings of the ascites suggested serous carcinoma. The resected ovaries and fallopian tubes were grossly and histologically normal. Histological examination of the solid part of broad ligament tumor, closely next to the fallopian tube, revealed a serous adenocarcinoma. Immunohistochemically, the tumor cells were strongly positive for CK7, WT-1, estrogen receptor, AE1/AE3 and EMA, and negative for CK20, D2-40 and calretinin. Also, they were negative for progesterone receptor and p53. The authors diagnosed the primary tumor as being a serous cystadenocarcinoma of the broad ligament [pTIC3NxM0, as modified and adapted to post-surgical staging of ovarian cancer (FIGO 2014)]. The patient has been receiving 6 cycles of adjuvant chemotherapies with one course with paclitaxel (PTX) and carboplatin (CBDCA) and five with PTX, CBDCA and Bevacizumab, and has no signs of recurrence and metastasis six months after the operation.