TITLE:
Maternal Serum Lipids in Pre-Eclamptic and Normotensive Pregnant Women: A Case-Control Study
AUTHORS:
Olumide Emmanuel Adewara, Adeleye Niyi Ogundolire, Adebayo Augustine Adeniyi, Segun Murtala Ghazali, Sunday Babatunde Awoyinka, Idowu Adebara, Olumide Mojisola Ayankunle, Ayokunle Moses Olumodeji, Olabisi Timothy Adeyemo, Adewumi Bakare
KEYWORDS:
Pregnancy and Serum Lipids, Serum Lipids and Preeclampsia, Preeclampsia
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.11 No.11,
November
25,
2021
ABSTRACT: Background: Preeclampsia-eclampsia
is a major contributor to maternal and fetal, morbidity and mortality
especially in low to middle income countries. This hypertensive disorder of
pregnancy remains a disease of theories due to its unclear etiology. We
evaluated for possible associations between maternal serum lipids and
preeclampsia. Methods: This was a prospective case-control study that
recruited 60 consenting women diagnosed with preeclampsia (cases) and 60
normotensive healthy pregnant women (controls), matched for maternal age and
gestational age over an 8-month period (18th June, 2014 to 18th February, 2015) at the Federal Teaching Hospital Ido-Ekiti, Nigeria. Cases and
controls were recruited using the non-probability convenience sampling. Fasting
venous blood samples were collected in both cases and controls and analyzed for
serum total cholesterol (TC), triglycerides (TG), high density lipoproteins
(HDL) and low density lipoproteins (LDL) using Randox standard enzymatic
methods. Data obtained were analyzed using SPSS version 18 to compare and test
for significance using Student t-test, Chi-square, and Pearson’s correlation as
the appropriate. Tests of association were determined using logistic regression
models. The difference was considered significant at P Findings: The mean serum levels of TC, HDL and LDL were significantly (p Conclusion: Elevated
maternal serum lipids are associated with preeclampsia, however, the widespread
lack of uniformity in the patterns of dyslipidemias in pre-eclamptics, across
different populations, may suggest that serum lipids will not be a reliable
predictor or severity marker of preeclampsia.