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Itskovitz, J., Boldes, R., Barlev, A., Erlik, Y., Kahana, L. and Brandes, J.M. (1988) The Introduction of LH Surge and Oocyte Maturation by GnRH Analog (Buserelin) in Women Undergoing Ovarian Stimulation for in Vitro fertilization. Gynecological Endocrinology, 2, 165.

has been cited by the following article:

• TITLE: GnRH-Agonist Trigger versus Human Chorionic Gonadotrophin (HCG) Trigger in Cases of Controlled Ovarian Stimulation; Randomized Controlled Trial

  AUTHORS: Mohamed Elmahdy, Suzan Elsharkawy

  KEYWORDS: GnRH Agonist, HCG, Ovulation Trigger, OHSS

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.11 No.11, November 10, 2021

  ABSTRACT: Objectives: The aim of the study was to compare the efficacy and safety of GnRH-agonist to the human chorionic gonadotrophin (HCG) trigger in cases of simple ovarian stimulation. Study design: Randomized controlled trial was conducted on 291 women complaining of unexplained infertility visiting Elshatby Maternity University Hospital from February to December 2019. Trial registration unique ID is PACTR202001787868341 (https://www.pactr.org/). Age included from 20 - 43 years. All patients were stimulated by the sequential stimulation protocol using letrozole then FSH injection, when the criteria of ovulation trigger were reached; cases were randomized into two groups using closed envelopes method. Group A (123 cases) GnRh agonist (triptorelin 0.2 IU) subcutaneous injection and Group B (168 cases) HCG 10,000 IU intramuscular injection were used for triggering of ovulation then followed by timed intercourse. Results: Primary outcome was the clinical pregnancy rate while rate of miscarriage and ovarian hyper-stimulation rate were the secondary outcome. Clinical pregnancy rates, in Group A were (21.1%) while it was (31.5%) in another group (P = 0.049). Miscarriage rate was (4.9%) in the first group and (3.6%) in the second group (P = 0.580). Except for one case of moderate ovarian hyper-stimulation syndrome (OHSS) complicated the HCG group, there were no such cases in GnRH group. Conclusion: Triggering final oocyte maturation with HCG was superior to GnRH agonists triggers as regards the clinical pregnancy rate.