TITLE:
Cardio-Toxicity during chemotherapy: feasibility of new diagnostic approaches
AUTHORS:
Fable Zustovich, Mario Trivellato, Renato Ceravolo, Davide Pastorelli, Rosanna Canton, Lorena Buratin, Monica Mion, Martina Zaninotto, Martina Mattiazzi, Mario Plebani, Giuseppe Cartei
KEYWORDS:
Cardio-Toxicity Diagnostic
JOURNAL NAME:
Health,
Vol.2 No.4,
May
4,
2010
ABSTRACT: Chemotherapy induced cardio-toxicity is a well known side effect of anticancer treatments, moreover the 70% of all tumors involve patients over 65 years-old, frequently with cardiac co- morbidity. We evaluated the feasibility of the application during chemotherapy administration of some of the most recent diagnostic techniques as 12-diagnostic leads telemetry, 7 days EKG monitoring device (R-Test Evolution 3R), blood level dosage of Brain Natriuretic Peptide (BNP) and Ischemia Modified Albumin (IMA). Some sub-clinical changes in the investigated parameters were found in patients undergoing chemotherapy, mostly containing fluorouracil, as shown in the following paper. Far from suggesting a widespread use of these methods during chemotherapy administration, we think that some more tools are needed to prevent cardiac toxicity in high-risk patients and some of what we studied may deserve further valuation in chemotherapy clinical trials.