TITLE:
Investigation on the Distribution of Common Thalassemias in Various Cities and Counties under the Jurisdiction of Chongzuo City, Guangxi
AUTHORS:
Huan Zhao, Yan Chen, Jing Lan, Liuxian Huang, Tianyou Huang, Miaohong Li, Xingchuang Chen, Wanwei Yang, Fu Huang, Tongfeng Huang, Xiuge Li
KEYWORDS:
Thalassemia, α-Thalassaemia Gene, β-Thalassaemia Gene, Distribution Status, Gene Analysis
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.12 No.11,
November
5,
2021
ABSTRACT: Objective: To understand the distribution of thalassemia in all
districts under the jurisdiction of Chongzuo City. Methods: Collect
blood routine indicators from May 2014 to 31 December 2020 in the districts of
this city to screen out suspected Mediterranean patients for genetic diagnosis;
GGAP-PCR and PCR-reverse dot hybridization were used to analyze the thalassemia
gene in the specimens of suspected patients; compare the prevalence of
thalassemia in the counties and cities within the jurisdiction of this city,
and provide corresponding medical advice to the health authorities. Results: 21,535 venous blood specimens from patients with suspected thalassemia were
collected in the city. There were 14,215 positive cases of thalassemia,
accounting for 66.01% of the total number of patients, among which 9455 cases
(43.91%) were pure α gene positive.
3464 patients (16.09%) were positive for simple β gene. 1296 patients (6.02%) were positive for αβ double gene. The proportions of
thalassemia gene testing for α-thalassaemia
gene, β-thalassaemia gene, and α-β double gene in various counties and districts were different. According to the multiple
rate or the chi-square test of the constituent ratio, the comparison of the
distribution of the thalassaemia gene test results in each area, χ2 = 472.6917, P = 0.0000,
the difference is statistically significant. Conclusion: Severe thalassemia
is a tragedy for a family. It not only needs to spend a lot of money to prolong
life, but it also cannot change the situation of losing life and financial
emptiness in the end. It is suggested that timely screening, timely diagnosis
and medical consultation should be carried out in married
and unborn families and early pregnancy, so as to reduce the birth of
children with severe thalassemia and avoid the occurrence of tragedies.