TITLE:
Etiologies of Liver Cytolysis in the Service of Hepato-Gastroenterology of the Gabriel Toure University Hospital
AUTHORS:
Hourouma Sow wife Coulibaly, Kadiatou Doumbia wife Samaké, Moussa Younoussa Dicko, Deborah Sanogo wife Sidibé, Makan Siré Tounkara, Ousmane Diarra, Anselme Konaté, Moussa Tiemoko Diarra, Moussa Youssoufa Maiga
KEYWORDS:
Liver Cytolysis, Transaminases, Etiology, Mali
JOURNAL NAME:
Open Journal of Gastroenterology,
Vol.11 No.11,
November
4,
2021
ABSTRACT: Aggression to the liver by xenobiotic and endogenous agents essentially
results in an increase in serum aminotransferases related to hepatic cytolysis,
the diagnosis of which is not always easy due to the diversity of its causes.
This was a cross-sectional study from April 2019 to March 2020 that took place
in the Department of Hepato-gastroenterology of the Gabriel Touré University
Hospital Center. This was a cross-sectional study from April 2019 to March 2020
which took place in the Hepato Gastroenterology department of the Gabriel Touré
university hospital whose objective of which was to study the etiology of
hepatic cytolysis. We included all patients with hepatic cytolysis resulting in
increased aminotransferase alanine at a rate higher than the normal upper limit
with or without an increase of aspartate aminotransferase. We collected
199/2800 patients who met our inclusion criteria, i.e., a
frequency of 7.1%. The mean age was 44.06 years ± 16.4 years, the sex ratio was
1.73. The most common clinical signs were jaundice, ascites, hepatomegaly,
asthenia and anorexia. Biologically, chronic cytolysis was noted with a moderate
elevation of aminotransferase alanine in 77.9% and a significant elevation in
15.5% of cases. HBs antigen (HBsAg) was positive in 80 patients (40.2%) and
anti-hepatitis C virus (HCV) antibody in 18 patients (9%). Abdominal ultrasound
was the first-line morphological examination and hepatomegaly alone or
associated with splenomegaly was the most common abnormality. The main causes
of acute cytolysis were viral hepatitis B, bile duct obstructions, drug-induced
hepatitis and malaria while chronic cytolysis was mainly due to cirrhosis and
hepatocellular carcinoma (HCC).