TITLE:
Anti-Melanogenesis Effect of Daniellic Acid Isolated from Daniellia oliveri (Rolfe) Hutch. & Dalziel (Leguminosae) Oleoresin of Burkina Faso
AUTHORS:
Aminata P. Nacoulma, Moussa Compaoré, Naamwin-so-Bawfu Romaric Meda, Laurent Pottier, Véronique Megalizzi, Issa Some, Martin Kiendrebeogo
KEYWORDS:
Daniellia oliveri, Daniellic Acid, Tyrosinase, Melanogenesis, Cytotoxicity
JOURNAL NAME:
Open Journal of Medicinal Chemistry,
Vol.11 No.4,
November
1,
2021
ABSTRACT: Over the past years, natural products have been used as useful candidates
for prevention and treatment of skin disorders such as skin darkening. In this
current research, Daniellia oliveri which was a potential source of
cosmeceutical agent was selected to investigate its active components.
Daniellic acid isolated from the oleoresin was characterized by using data from 1H-NMR, 13C-NMR, HSQC, IR, and online chemo-informatic
analysis. The daniellic acid antioxidant, anti-proliferative, and tyrosinase
inhibition capabilities were evaluated. This compound possessed an anti-DPPH
and iron (III) reducing effect compared to quercetin. It was able to inhibit 9
tumor cells with IC50 going from 0.03 mM (U373) to 0.14 mM
(Malme-3M). Interestingly daniellic acid inhibits tyrosinase activity with 1.20 mM as IC50. The tyrosinase inhibition
mechanism was noncompetitive mixed-type with un-significant effect on cell
melanogenesis. Daniellic acids induced a half-reduction of melanin production
in B16F10 cell in IBMX stimulation (p 0.05).
The same observation was effective in Malme-3M melanin production with a
significant daniellic acid action than kojic acid (p 0.05)
without reducing cell viabilities. This bioactive daniellic acid could explain
the traditional uses of oleoresins from Daniellia oliveri for
genitor-urinary tract diseases treatments, wound healing, and skin ailments in
Burkina Faso.