TITLE:
Composition of Human Atheroma Collected from Coronary Arteries during Coronary Artery Bypass Surgery
AUTHORS:
Mayank Acharya, Pranab Karmaker, Md. Moniruzzaman, Abu Hasan, Sumiya Aktar, Asit Baran Adhikary, Mala Khan
KEYWORDS:
Atheroma, Coronary Artery Disease, Arteriosclerosis
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.12 No.10,
October
28,
2021
ABSTRACT: Coronary arteries supply blood and nutrients to the
heart. Coronary Artery Disease (CAD) develops by narrowing of the arteries.
Once the inner walls of the arteries are damaged, fatty deposits made of cells,
connective tissue elements, lipids and debris decrease their lumens which block
blood flow to distal tissues. This process is called arteriosclerosis. This
study intends to detect the composition of
human coronary atheroma collected from the arteries during bypass
surgeries in Bangladesh. It shows that all lesions are present in the advanced
types, namely, type 4, 5 and 6. Infrequently thrombotic materials and necrotic
debris were found in type 6 plaque. The mean length of plaque was 3.36 ± 1.71
cm and mean weight was 0.13 ± 0.12 gm. Insufficient lipid was obtained from
each atheroma. Few raised areas were lipid laden whereas most of the strands were fibrous. Biochemical
assessment was formidable. The cholesterol composition of coronary
plaque ranged between 0.20% - 9.83% with mean 3.06% ± 2.09% and total fatty acids
ranged between 0.47% - 3.04% with mean 1.31% ± 0.63%. The most abundant fatty
acid was oleic acid (unsaturated) closely followed by palmitic acid
(saturated). The mean calcium content was 41,180.20 ± 34,918.59 ppm and ranged
from 1148.00 - 140,311.00 ppm or, 0.115% - 14.031%. This study was undertaken
to detect the composition of human coronary atheroma in Bangladesh which
revealed that it depended upon the type of lesion.