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Lewis, J.S., Westra, W.H., Thompson, L.D., Barnes, L., Cardesa, A., Hunt, J.L., Williams, M.D., Slootweg, P.J., Triantafyllou, A., Woolgar, J.A., Devaney, K.O., Rinaldo, A. and Ferlito, A. (2014) The Sinonasal Tract: Another Potential “Hot Spot” for Carcinomas with Transcriptionally-Active Human Papillomavirus. Head and Neck Pathology, 8, 241-249.
https://doi.org/10.1007/s12105-013-0514-4

has been cited by the following article:

• TITLE: Clinical Variants, Rates of Post-Operative Recurrence and Malignant Transformation of Sino-Nasal Inverted Papilloma

  AUTHORS: Israa M. Qadmi, Alaa Q. Mandeel, Jehad H. Hammad, Reem J. Radhi, Sayed Ali I. Al Mahari

  KEYWORDS: Bahrain, Clinical Risk Factors, Malignant Transformation, Sino-Nasal Inverted Papilloma, Smoking, Salmaniya Medical Complex

  JOURNAL NAME: International Journal of Otolaryngology and Head & Neck Surgery, Vol.10 No.6, October 21, 2021

  ABSTRACT: Background: Inverted Papilloma (IP) is the most common benign neoplasms arising from the mucosal lining of the of the Sino-Nasal tract with single or multifocal attachment sites. The high propensity to recur, local aggressive behavior and possibility of malignant transformation attract considerable interest. Objective: To assess the factors affecting Sino-nasal IP, malignant transformation rate, and post-operative recurrence rate. Methods: A retrospective study was carried out on all cases diagnosed as Sino-Nasal Papilloma between January 2010 and December 2020 at Salmaniya Medical Complex, Bahrain. Data gathered from medical records were analyzed using SPSS. A total of 49 Sino-Nasal Papilloma cases were recorded of which 37 were IP. Factors affecting Sino-Nasal IPs are presented. Results: Sino-Nasal IP was recorded in 37 cases, composed of 28 males and 9 females with first presentation average age of 45.86 years. These involved 20 cases in the left side, 14 in the right side and 3 were bilateral. Recurrence in males and females was found to be 35.7% and 33%, respectively, with an average of 12.6 months. The symptoms include nasal blockage (97.3%), epistaxis and postnasal drip (13.5% each), headache (8.1%) and hyposmia and rhinorrhea (5.4%, each). The main recurrence was at stage T2 (60.5%), while in smokers (26.7%) and non-smokers (50%). Malignant transformation occurred in one patient only (2.6%). Conclusion: IP is the most common type of SNP with male predominance. The recurrence rate is high with an average of a year and the malignant transformation occurred in 2.6 % of the cases.