TITLE:
Clinical Efficacy of Shenmai Injection in the Treatment of Cerebral Vasospasm after Ruptured Aneurysm Surgery
AUTHORS:
Tianya Wu, Jingxin Fu, Xinghuo Jin, Qichao Chen, Huanming Huang, Shiqi Chen, Jun’an Zhou, Longbiao Xu
KEYWORDS:
Shenmai Injection, Nimodipine, Ruptured Aneurysm, Aneurysmal Subarachnoid Hemorrhage, Cerebral Vasospasm
JOURNAL NAME:
Case Reports in Clinical Medicine,
Vol.10 No.10,
October
13,
2021
ABSTRACT: Objective: To investigate the therapeutic effect of Shenmai Injection on postoperative cerebral vasospasm in patients with ruptured aneurysms. Methods: Seventy patients undergoing craniotomy for ruptured aneurysms in our hospital were selected as study subjects and randomly divided into control (n = 33) and research (n = 37) groups, they were treated with nimodipine and nimodipine combined with Shenmai injection after operation. The blood flow velocity in the middle cerebral artery (MCA) before and at 1, 3, 7, 11 and 14 days after surgery and the incidence of cerebral vasospasm during these days were compared, and the GCS scores at 14 days postoperatively and GOS scores at 6 months postoperatively were compared between the two groups. Results: There were no statistically significant differences in the occurrence of cerebral vasospasm, GCS or GOS scores between the two groups (P > 0.05), but the period of postoperative cerebral vasospasm in the study group was significantly shorter than that in the control group. Conclusion: Shenmai injection has the effect of shortening the cycle of occurrence of cerebral vasospasm after the operation of ruptured aneurysms, promoting patients to recover as early as possible and reducing their physical and mental burden.