TITLE:
About a Case of Chronic Myeloid Leukemia and Pregnancy
AUTHORS:
M. A. D. Sengeyi, S. J. Mokassa, A. J. Lumaya, M. R. Mbungu, J. J. Malemba
KEYWORDS:
Chronic Myeloid Leukemia, Pregnancy, Tyrosine Kinase Inhibitors
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.11 No.9,
September
16,
2021
ABSTRACT: Chronic
myeloid leukemia (CML) associated with pregnancy is a very rare situation (less
than one case per 100,000 pregnancies). It raises a serious ethical and therapeutic problem because chemotherapy
during pregnancy can expose the fetus to various complications such as
congenital malformations, abortion and intra uterine growth restriction. Inhibitors of tyrosine
kinase are the most widely used molecules but without much certainly about
their non-teratogenic effects. This is a report case of pregnancy occurring in
a patient with Imatinib for CML replaced by Hydrea who gave birth to a healthy
newborn with no congenital malformation.