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Zhang, N., Liang, M., Zhang, D.D., Xiao, Y.R., Li, Y.Z., Gao, Y.G., Cai, H.D., Lin, X.Z., Lin, C.Z., Zeng, K. and Wu, X.D. (2018) Effect of Goal-Directed Fluid Therapy on Early Cognitive Function in Elderly Patients with Spinal Stenosis: A Case-Control Study. International Journal of Surgery, 54, 201-205.
https://doi.org/10.1016/j.ijsu.2018.04.007

has been cited by the following article:

• TITLE: Effect of Goal-Directed Fluid Therapy on Lung Function, Cognitive Function and Inflammatory Response in Patients Undergoing Radical Esophageal Cancer Surgery under One-Lung Ventilation

  AUTHORS: Jibo Zhao, Yuanli Li, Dengyun Xia, Xiaojia Sun, Yuan Zhang, Fulong Li, Jinliang Teng

  KEYWORDS: Goal-Directed Fluid Therapy, Radical Resection of Esophageal Cancer, Lung Function, Cognitive Function, Inflammatory Response

  JOURNAL NAME: Journal of Cancer Therapy, Vol.12 No.9, September 8, 2021

  ABSTRACT: Objective: To explore the effects of goal-directed fluid therapy (GDFT) on lung function, cognitive function and inflammatory response in patients undergoing radical esophageal cancer surgery under one-lung ventilation. Methods: Sixty-seven patients undergoing radical esophageal cancer surgery were divided into GDFT group (GDFT therapy) and control group (conventional liquid therapy). The changes in patients’ pulmonary function, cognitive function and inflammatory response were evaluated. Results: Both alveolar-arterial oxygen partial pressure difference [P(A-a)O2] and respiratory index (RI) increased at one-lung ventilation for 30 minutes (T2) and decreased at one-lung ventilation for 60 minutes (T3), and after surgery (T4) in the two groups, and the GDFT group was lower than the control group (P 0.05); theoxygenation index (OI) of the two groups decreased at T2, T3, and T4 compared with that at T1 (before one-lung ventilation), and the GDFT group was higher than the control group (P 0.05). At T4 and T5, the tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), central nervous system specific protein (S100β), and neuron specific enolase (NSE) in the GDFT group were lower compared to the control group (P 0.05), while interleukin-10 (IL-10) was higher compared to the control group (P 0.05); the incidence of perioperative neurocognitive disorder (PND) in the GDFT group was lower than that in the control group (P 0.05). Conclusion: GDFT can help prevent lung injury during radical esophageal cancer surgery under one-lung ventilation, reduce the body’s inflammatory response, and reduce the incidence of perioperative cognitive disorder to a certain extent.