TITLE:
ICSI with All Oocytes Recurrent Metaphase I Characterized by Absence Perivitelline Space
AUTHORS:
Yan Jiang, Ge Song, Jingchuan Yuan, Xuhui Zhang
KEYWORDS:
ICSI, Recurrent MI Oocyte Arrest, AOA, Ionomycin
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.11 No.9,
September
6,
2021
ABSTRACT: Previous
cases reported recurrent all oocytes in repeated cycles were arrested at MI
failed to mature after culture and ICSI resulted in total nonfertilization.
Ionomycin induced first PB extrusion in patients with recurrent
maturation-resistant MI oocytes. ICSI combined with assisted oocyte activation (AOA)
on MII oocytes matured in vitro resulted in abnormal fertilization with no
further embryo cleavage potential. The objective of this work was to research
if AOA helpful to fertilization for recurrent maturation-resistant MI oocytes.
In this case, patient both cycles retrievaled immature MI oocytes characterized
by absence perivitelline space (APVS). In the second cycle, ionomycin was used
for AOA after MI oocyte perfomed ICSI, no fertilization again.