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Neve, J., Wijesekera, H., Duffy, S., Jenkins, I., Ripper, J., Teague, S., et al. (2014) Euodenine A: A Small-Molecule Agonist of Human TLR4. Journal of Medicinal Chemistry, 57, 1252-1275.
https://doi.org/10.1021/jm401321v

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• TITLE: Differential Effects of Ursolic Acid and Oleanolic Acid on Mitochondrial ATP Generation in H9c2 Cardiomyocytes and Lipopolysaccharide-Induced Cell Proliferation in Mouse Splenocytes: Yang versus Yin

  AUTHORS: Hoi Yan Leung, Kai Chit Cheung, Kam Ming Ko

  KEYWORDS: Yang, Yin, Ursolic Acid, Oleanolic Acid, Mitochondrial ATP Generation, Splenocytes

  JOURNAL NAME: Chinese Medicine, Vol.12 No.3, September 3, 2021

  ABSTRACT: In the present study, two cell-based systems for assessing Yang and Yin activities were for the first time used to investigate the effect of ursolic acid (UA) and oleanolic acid (OA). The results indicated that while UA was only active in the Yang assay, OA produced activity in the Yin assay. The Yang/Yin activity of UA/OA may be attributed to their distinct molecular structures, which confer their differential ability to interact with mitochondrial membrane or cellular membrane lipids, with resultant membrane fluidization and potentiation of biological responses.