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Kevadiya, B., Rahul, P., Mahendrapalsingh, M., Shalini, R., Harshad, B., Joshi, G., Ganga, P., Haresh, M., Pankaj, K. and Bajaj, H. (2012) Montmorillonite/Poly-(ɛ-Caprolactone) Composites as Versatile Layered Material: Reservoirs for Anticancer Drug and Controlled Release Property. European Journal of Pharmaceutical Sciences, 47, 265-272.
https://doi.org/10.1016/j.ejps.2012.04.009

has been cited by the following article:

• TITLE: Intercalation of Ciprofloxacin in Naturally Occurring Smectite from Bana: Potentiality as Drug Delivery System and Antimicrobial Effects on Escherichia coli and Staphylococcus aureus

  AUTHORS: Carine Feudjio Memenfo, Nicolas Tabary, Jean Aimé Mbey, Stéphanie Degoutin, Frédéric Cazaux, Maryse Bacquet, Mickaël Maton, Bernard Martel, Daniel Njopwouo

  KEYWORDS: Antibacterial Effect, Drug Delivery System, Clay, Ciprofloxacin, Intercalation

  JOURNAL NAME: Journal of Materials Science and Chemical Engineering, Vol.9 No.8, August 26, 2021

  ABSTRACT: Ciprofloxacin (CFX) was loaded on Bana clay (Cameroon) and CFX loaded-clays have been evaluated as drug delivery system. Raw clays and CFX loaded compounds have been characterized by some physico-chemicals methods. In vitro release studies have been done in gastric and phosphate buffer experimental mediums; bacteriological studies have been made up on Escherichia coli and Staphylococcus aureus. X-ray diffractometry patterns of loaded compounds show a basal spacing increasing due to CFX intercalation. On Fourier-Transformed Infrared spectrometry spectra, appearance of CFX characteristic bands and shifting of certain bands already presents on clay confirmed CFX intercalation. After 96 h of CFX released from release mediums, prolonged and continue profiles have been observed. Diffusion tests displayed an inhibition radius of ~2 cm on gelose seeded with Escherichia coli and Staphylococcus aureus due to CFX. The overall results show a modified release of ciprofloxacin with an effective antibacterial activity, giving the way for a new ciprofloxacin drug delivery system using Bana clay as carrier.