TITLE:
Epidemiological, Diagnosis, Therapeutic and Evolving Profile of Triple Negative Breast Cancer in Senegal
AUTHORS:
Papa Macoumba Gaye, Mouhamed Diouf, Mouhamadou Bachir Ba, Doudou Diouf, Fatimatou Néné Sarr, Maimouna Mané, Mamadou Sarr, Mamadou Moustapha Dieng, Sidy Ka, Ahmadou Dem
KEYWORDS:
Breast Cancer, Triple Negative, Senegal
JOURNAL NAME:
Advances in Breast Cancer Research,
Vol.10 No.3,
July
23,
2021
ABSTRACT: Objective: Describe the epidemiological, diagnostic, therapeutic and evolutionary
profile of triple negative breast cancer at the Dakar Cancer Institute in
Senegal. Patients and Methods: This was a retrospective study between
January 1, 2011 and December 31, 2014. All patients with a triple negative
molecular profile were included. The data were collected from the medical
records of the patients. The data were entered and analyzed with SPSS edition
16 software under Windows 7. Results: Two hundred and twenty-five patients were selected. The
mean age was 47.9 ± 12.5 years with extremes of 25 and 90 years. The main
reason for consultation was dominated by the finding of a breast lump. The mean
clinical tumor size was 8, 54 cm with a large majority of T3-T4 tumors 26% and 63% respectively,
lymph node involvement in one hundred and seventy-two cases (76.4%); twenty
eight patients (12.4%) were metastatic from the outset. Non-specific invasive
carcinoma was the most common histologic type (78.2%), and more than half of
the patients (53.3%) had an aggressive tumor (Scarff-Bloom-Richardson grading
III). Neoadjuvant chemotherapy was performed in 65.78% of cases. We noted 27.7%
total response and 41.7% partial response in patients who have received this
neoadjuvant chemotherapy. The surgery was radical in 77% of cases, conservative
in 14% and cleanliness surgery for palliative purposes in 9% of cases. Adjuvant
radiotherapy is performed in 58.6% of operated patients. The mean time to
follow-up was 20.63 months with extremes of 1 and 53 months. Overall survival
was 69.8% at one year, 41.6% at two years and 25.6% at three years. Conclusion: The descriptive analysis of these results confirms the high frequency of
triple-negative breast cancer in Senegal and its poor prognosis.