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Glynne-Jones, R., Counsell, N., Quirke, P., Mortensen, N., Maraveyas, A., Meadows, H.M., Ledermann, J., et al. (2014) Chronicle: Results of a Randomised Phase III Trial in Locally Advanced Rectal Cancer after Neoadjuvant Chemoradiation Randomising Postoperative Adjuvant Capecitabine plus Oxaliplatin (XELOX) versus Control. Annals of Oncology: Official Journal of the European Society for Medical Oncology, 25, 1356-1362.
https://doi.org/10.1093/annonc/mdu147

has been cited by the following article:

• TITLE: Five Year Survival Outcomes of Prospectively Recorded Cohort Data for Older Adults versus Younger Adults with Resected Primary Rectal Cancer

  AUTHORS: Mohsen Shafiei, Philip Beale, Prunella Blinman

  KEYWORDS: Rectal Cancer, Chemotherapy, Radiotherapy, Overall Survival, Cancer Specific Survival

  JOURNAL NAME: Journal of Cancer Therapy, Vol.12 No.7, July 22, 2021

  ABSTRACT: Background: Rectal cancer predominantly occurs in older adults. We aimed to compare the long-term outcomes of older adults (≥70 years) versus younger adults (Methods: Consecutive patients who had resection of a primary rectal cancer between January 1, 2000 and December 31, 2010 were identified from a prospective database at the Concord Repatriation General Hospital and stratified into two age groups: ences in patients, cancer, and treatment characteristics were determined by Chi-square tests. 5-year Overall Survival (OS) and Cancer-Specific Survival (CSS) were determined by the Kaplan-Meier method and by multivariable Cox regression analysis. Results: Of 714 included patients, the mean age was 65.8 years (range, 21 - 92 years). 407 (57%) patients were aged 70 years. Older age (>70 years) predicted more comorbidity (p 70 years), compared with younger adults (Conclusion: Older adults who had had a resection of stage I-IV primary rectal cancer received less neoadjuvant and adjuvant therapy and had worse OS and CSS than their younger counterparts.