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Cheney, M.L., Shan, N., Healey, E.R., Hanna, M., Wojtas, L., Zaworotko, M.J., et al. (2010) Effects of Crystal Form on Solubility and Pharmacokinetics: A Crystal Engineering Case Study of Lamotrigine. Crystal Growth & Design, 10, 394-405. https://doi.org/10.1021/cg901010v

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• TITLE: Preparation of Carbamazepine-Nicotinamide Cocrystal

  AUTHORS: Huirong Ying, Jinna Zhang, Chengjun Jiang

  KEYWORDS: Carbamazepine, Nicotinamide, Cocrystal, Ultrasound

  JOURNAL NAME: Open Access Library Journal, Vol.8 No.7, July 20, 2021

  ABSTRACT: The focus of this investigation was to prepare the cocrystal of carbamazepine (CBZ) using nicotinamide as a coformer and to compare its different preparation methods. The cocrystal was prepared by grinding, solvent-Assisted grinding and ultrasound-assisted cocrystallization methods. They were characterized by Fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction (PXRD), and morphology by electron microscopy. In conclusion, ultrasound can be applied as a process intensification parameter along with cooling or slurry cocrystallization to produce pure cocrystals under conditions that might result in crystal mixtures in conventional processes.