TITLE:
Feasibility of Complete Cytoreduction in Advanced Epithelial Ovarian Cancer
AUTHORS:
Noha E. Hassan, Abdel Fattah Agameya, Amal Alsonoussi, Mahmoud Meleis
KEYWORDS:
Cytoreduction, Ovarian Carcinoma, Predictive Score
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.11 No.7,
July
9,
2021
ABSTRACT: Objective: Complete resectability of all visualized tumor
implants at debulking surgery for advanced epithelial ovarian cancer is
confirmed to be the single most important prognostic factor. This study
aims to develop preoperative predicting score based on clinical, biological, and radiological criteria of
epithelial ovarian cancer to assess the feasibility of complete cytoreduction. Study
Design: A retrospective record-based study. Patients and Methods: The
study was conducted upon 50 consecutive patients managed for epithelial ovarian
cancer with FIGO stage III. Patients’ data were collected from records of the
Gyne-Oncology Clinic of El Shatby University Maternity Hospital affiliated to Alexandria University. Results: Many parameters were significantly associated with completeness of
resectability in univariate analysis; including age, BMI, CA125, albumin,
pre-albumin, PCI, mesenteric, and right copula of diaphragm affection by CT
scan (p value .05). A 100-point
predictability score was developed, 10 for BMI ≥ 35 kg/m2, 25 points for Pre albumin points for
mesenteric affection, and 30 points for affection of Rt. copula of diaphragm. The
overall accuracy of the score was 92%. Conclusion: In advanced ovarian
cancer, pre-operative predicting score (including clinical, biological, and
radiological criteria) can be used as a roadmap for prediction of feasibility of
complete resectability. However, more research is needed on larger sample
sizes.