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Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S.I. and Tahara, H. (2006) Mitogenic Signalling and the p16 INK4a-Rb Pathway Cooperate to Enforce Irreversible Cellular Senescence. Nature Cell Biology, 8, 1291-1297.
https://doi.org/10.1038/ncb1491

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• TITLE: Verbascoside—A Review of Its Antitumor Activities

  AUTHORS: Hasan Alaa Aldeen Khalaf, Ruaa Azziz Jasim, Ismail Taha Ibrahim

  KEYWORDS: Verbascoside, Phenylethanoids, Phenylpropanoids, Glycosides, Cytotoxic, Antitumor

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.12 No.6, June 30, 2021

  ABSTRACT: Cancer is a set of diseases including abnormal growth of cells that can spread to another tissue. Verbascoside (or acteoside) is a naturally occurring, water-soluble secondary metabolite with significant biological properties, which is distributed widely in plant kingdom. Verbascoside is pharmacologically active compounds with many recent evidences that support its biological activities and safety. This review focuses on the recent studies that concerned with the antitumor activities of verbascoside alone and as a synergistic agent as well as nanoproduct. It also shows the latest advances in its antitumor effects, cytotoxic selectivity and its efficiencies in treating cancer, in vitro and/or vivo.