TITLE:
Prostate Cancer Characteristics and Associated Factors in Northern Cameroon
AUTHORS:
Tagne Simo Richard, Mohamadou Ahmadou, Nwabo Kamdje Armel Hervé, Seke Etet Paul Faustin, Baiguerel Erika Myriam, Danki Sillong Franklin, Telefo Phelix Bruno
KEYWORDS:
Cancer, Prostate, Gleason Score, Risk Factors, Africa
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.12 No.5,
May
28,
2021
ABSTRACT: Background: The incidence of prostate cancer
in Cameroon has been increasing in an alarming rate. The aim of this study
is to characterize the form of prostate cancer and associated factors in
patients from Cameroon Northern Regions. Methods: All patients with positive
prostate biopsy (cancer+) from June 2018 to November 2019 were studied (n =
177). The followings were retrieved: digital rectal examination, standard
clinical examinations, laboratory data such as serum prostate-specific antigen
(PSA) level, and the Gleason score. Patients self-administered a questionnaire
assessing prostate cancer’s risk factors. Results: Patients were mainly
from the Far North region (36.72%), and were either farmers or breeders
(48.01%). Only prostate adenocarcinoma was present, with predominance of
aggressive forms (Gleason score ≥ 7).
Significant relationships were observed between Gleason score and 1) patients’
age (P = 0.006), 2) history of urinary tract infections (P = 0.015) and of
exposure to agricultural products (P = 0.049), 3) clinical signs (nycturia,
pollakiuria, poor acute urine retention, and dysuria) (P = 0.019), 4)
prostate weight, and 5) serum PSA levels (P Conclusion: Aggressive forms
of adenocarcinoma are the main prostate cancer in these regions, underlining
the need for strategies aimed at raising prostate cancer awareness and early
detection.