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Gao, K., Wang, J., Li, L., Zhai, Y., Ren, Y., You, H., Wang, B., et al. (2016) Polymorphisms in Four Genes (KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China. International Journal of Environmental Research and Public Health, 13, Article No. 260.
https://doi.org/10.3390/ijerph13030260

has been cited by the following article:

• TITLE: Genetic Predisposition for Type 2 Diabetes Mellitus in a Cameroonian Population: Contribution of rs4731702 (C/T) Polymorphism of Krüppel-Like Factor 14 Gene

  AUTHORS: Magellan Guewo-Fokeng, Eugene Sobngwi, Barbara Atogho-Tiedeu, Eric Lontchi-Yimagou, Jean-Paul Chedjou, Jean-Claude Mbanya, Wilfred F. Mbacham

  KEYWORDS: Genetic, Krüppel-Like Factor 14 Gene, Type 2 Diabetes Mellitus, Cameroon

  JOURNAL NAME: Open Journal of Genetics, Vol.11 No.2, May 27, 2021

  ABSTRACT: Introduction: Krüppel Like Factor 14 (KLF14) gene has recently been identified as a master gene for multiple metabolic phenotypes. The aim of the research study was to investigate the relationship between KLF14 rs4731702 (C/T) gene polymorphism with Type 2 Diabetes Mellitus (T2DM) in a Cameroonian population. Patients and Methods: This case-control study was conducted in 85 patients with T2DM and 95 healthy normoglycemic controls. All were nonrelated, of Cameroonian origin, and were adults aged 24 years old and above. Demographic, clinical and biological data were collected, and biochemical explorations were performed using enzymatic colorimetric methods. The genotyping of KLF14 rs4731702 (CT) gene polymorphism was done by the Polymerase Chain Reaction and Restriction Fragment Length Polymorphism. Results: In comparing the Cameroonian population that consisted of 85 patients with T2DM and 95 healthy controls, the minor or risk allele of the rs4731702 (C/T) polymorphism of the KLF14 gene was T (63.53% diabetic patients vs. 26.32% healthy controls, OR = 4.877 and p Conclusion: This study has demonstrated for the first time the relationship between the KLF14 rs4731702 (C/T) gene polymorphism and T2DM in this Cameroonian population. This gene polymorphism could be a promising target for personalized medicine through the development of clinical genetic testing.