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Kantidze, O.L., Luzhin, A.V., Nizovtseva, E.V., Safina, A., Valieva, M.E. and Golov,A.K., et al. (2019) The Anti-Cancer Drugs Curaxins Target Spatial Genome Organization. Nature Communications, 10, Article No. 1441. https://doi.org/10.1038/s41467-019-09500-7

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• TITLE: A Novel Strategy for Preventing and Treating Cancer: Alteration of Cancer-Associated Chromatin Configuration

  AUTHORS: Gao-De Li

  KEYWORDS: Cancer, Cancer-Associated Chromatin Configuration (CACC), Non-Carcinogenic Genotoxic Drugs (NCGDs), Cancer Prevention, Cancer Treatment

  JOURNAL NAME: Open Access Library Journal, Vol.8 No.5, May 6, 2021

  ABSTRACT: The hallmarks of cancer are determined by cancer-associated gene expression pattern that is determined by cancer-associated chromatin configuration (CACC). Using non-carcinogenic genotoxic drugs (NCGDs) to alter CACC could change cancer-associated gene expression pattern, which in turn, might cause disappearance of some or whole hallmarks of cancer and as a result, cancer cells could be killed by either apoptosis or immune destruction. Therefore, cancer could be prevented and treated by administration of NCGDs that can alter CACC in cancer cells.