TITLE:
Neuroplasticity in Spinal Trauma: A Current Narrative Review of Treatments
AUTHORS:
Vinicius Benatti Freire, Lucas Cressoni de Souza, Mario Henrique de Lima Martinelli, Leonardo Moysés Sacchi, Thales Andolfo de Souza, Antonio Eduardo Damin
KEYWORDS:
Neuroplasticity, Spinal Cord Injury, Regeneration, Nanomaterials, Stem Cell, Pharmacology
JOURNAL NAME:
World Journal of Neuroscience,
Vol.11 No.2,
April
21,
2021
ABSTRACT: Neuroplasticity is a condition that is present from birth, being found in
the central and peripheral nervous system, in both physiological and
pathological terms. Based on the findings, therapeutic and non-therapeutic
attempts were tested on spinal cord trauma to recover locomotor function below
the level of the injury. The work defined and showed other forms of the term
neuroplasticity, talk about some pathological and non-pathological conditions,
and, finally, show neuroplasticity and some of its treatments in the spinal
cord injury process. A narrative literature review from 2000 to 2020 of the
PubMed platform was conducted and analysis of two books for the elaboration of
this work. Animal/human studies were
included that addressed pathologies, forms of treatment for spinal
trauma, and qualis from B1 to A1. Pre-2000 articles, which addressed
neuroplasticity only to understand the molecular mechanisms and articles that
were not in English, were excluded. As a result, the main molecules and
structures that inhibit neuroplasticity were found, and, based on their
knowledge, forms of treatments were developed to inhibit these molecules and
structures to assist in neuroplasticity and assist in possible functional
recovery. It can be concluded that the physiological barriers are already being
overcome by the most recent forms of treatment and that soon new studies may
propose a form of treatment that is protocoled for all patients.