TITLE:
Sildenafil plus Low Dose Aspirin for Prevention of Preeclampsia: A Randomized Controlled Trial
AUTHORS:
Mahmoud Mohamed Ghaleb, Youssef Sobhy Labib, Karim Ahmed Wahba
KEYWORDS:
Preeclampsia, Hypertension, Placental Disease, Pregnancy Complications, As-pirin, Sildenafil Citrate
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.11 No.2,
February
25,
2021
ABSTRACT: Objective: To compare
between the efficacy of the use of oral sildenafil plus low dose aspirin versus
the use of oral low dose aspirin alone in pregnancy as preventive measure in women
at risk for preeclampsia (PE). Design: A randomized clinical trial. Setting: Outpatient Obstetric clinic of Ain Shams University Maternity Hospital. Population
or sample: Women at gestational age of ≤16 weeks who at risk for PE between June 2018 and June 2019. Methods: Participants were randomly allocated into two groups: Group I Included 200 women
who received a 25 mg tablet of oral sildenafil citrate tid until delivery plus 100
mg tablet of aspirin orally once daily until gestational age of 36 weeks, Group
II Included 200 women who received a 100 mg tablet of aspirin orally once daily
until gestational age of 36 weeks. Main Outcome Measures: Incidence of preeclampsia
diagnosed per ACOG criteria. Results: The incidence of PE in both groups
showed no statistically significant difference. The incidence of PE in the first
group is 11.0%, and it is 12.0% in the second group (p-value 0.754). Conclusion: The addition of sildenafil citrate to low dose aspirin had no impact on the prevention
of preeclampsia for women at risk of PE, in addition, sildenafil did not improve
maternal and fetal outcomes.