TITLE:
Selenium’s Utility in Mercury Toxicity: A Mini-Review
AUTHORS:
Roswell Timmerman, Stanley T. Omaye
KEYWORDS:
Mercury, Selenium, Toxicity, Selenoproteins, Human Health, Oxidative Stress
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.12 No.2,
February
18,
2021
ABSTRACT: Purpose: This review of the literature intends to provide readers an understanding
of the prophylactic and antidotal usefulness of selenium (Se) for mercury (Hg)
toxicity. We will provide an explanation of Hg and Se interactions for
potential remediation options to contaminated ecosystems. Design/methodology/approach: In this mini-review, we discuss mechanistic aspects between Hg and Se, the
implication for health outcomes, and its usefulness in the ecological recovery
of Hg contaminated areas. Findings: Mercury has a strong affinity for Se,
resulting in Se-dependent enzymes and proteins’ deactivation with devastating
consequences to the host. It is likely that Hg’s toxicity results in Se
deficiency. Selenium compounds can have prophylactic or antidotal effects to
prevent or reverse the adverse toxicity action of Hg exposure. Current research
indicates that the chemical interactions between Hg and Se are unique. The Hg
capturing capacity of Se is a million times higher than sulfur compounds and
results in inactive complexes. Practical implications: Future work can
target engineering methods for technologies that can reduce the toxicity of Hg
in the environment. Originality/value: The unique interactions between the elements are
that Hg can compromise Se dependent enzymes; however, pharmacologic doses of Se
can prevent or modulate the toxic effects of Hg. Paper
type: Literature
review.