TITLE:
Synthesis, Characterization, Antimicrobial and DNA Binding Studies of a Tetradentate N2O2 Amino Acid Schiff Base and Its Coordination Compounds
AUTHORS:
Temitayo O. Aiyelabola, Daniel P. Otto, Johan H. L. Jordaan, Ezekiel O. Akinkunmi, Idowu Olawuni
KEYWORDS:
CT-DNA, DNA Binding, Antimicrobial, Coordination Compound, Molecular Docking, Schiff Base
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.11 No.1,
February
10,
2021
ABSTRACT: Aminoethanoic acid undergoes condensation with 1,4-benzenedicarboxaldehyde to form an O, N, N, O donor Schiff base, N,N'-di(carboxymethylene) terephthalaldehyde,
Ligand L. Coordination compounds of this Schiff base using Ni (II), Cu (II), VO (IV) and Co (II) were then
obtained in-situ. The Schiff base and the complexes were evaluated
for their antimicrobial and DNA binding abilities. Molecular docking studies of
the ligand and synthesized compounds were also carried out. Evidence for the
formation of the Schiff base coordination compounds and the coordinating atoms
was obtained from 1H NMR, infrared and ultraviolet spectral data,
EDX, EDTA complexometric titration and magnetic susceptibility measurement. The
results obtained are consistent with octahedral geometry for Ni (II) complex, the
metal ion coordinating to one molecule of Ligand L and with additional coordination with two oxygen atoms of two molecules of
the solvent. A square-planar geometry was suggested for both Co (II), and Cu
(II) complexes and a five-coordinate, square pyramidal geometry for the VO (IV)
complex. The results further indicated that the carboxylic acid of Ligand L was
not deprotonated both in the free base and also the complexes. In addition, the
results showed that Compound 2 elicited the best antimicrobial activity
potential. Generally, the compounds exhibited considerable good affinity to
CT-DNA.