TITLE:
Rejuvenation of Ovary and Thin Endometrium by Autologous PRP Injection in POR and Recurrent Implantation Failure
AUTHORS:
Yazhini Selvaraj, Kanchana Malaisamy
KEYWORDS:
Platelet Rich Plasma (PRP), Poor Ovarian Reserve (POR), Premature Ovarian Insufficiency (POI), Anti Mullerian Hormone (AMH), Antral Follicle Counts (AFC), Intra Cytoplasmic Sperm Injection (ICSI), Outpatient Procedure (OP)
JOURNAL NAME:
Advances in Sexual Medicine,
Vol.11 No.1,
January
30,
2021
ABSTRACT: In India, the problem of infertility
is growing and in the last 5 years, it has gone up to 20% - 30%. This ongoing prospective clinical study brings
forth a novel, innovative, effective, simple, affordable, easily performed
outpatient procedure (OP) and a promising therapeutic method in rejuvenating
the Ageing Ovaries and Thin Endometrium, with autologous Platelet Rich Plasma
(PRP). This clinical study proves to give a better result in rejuvenating Ovary
and treating the Thin Endometrium. This pilot study included five women (28 - 44 years) with Poor
Ovarian Response (POR), Premature Ovarian Insufficiency (POI) and Perimenopause
and Thirty-nine women (22 - 43 years.) with recurrent implantation failure due to
Thin Endometrium were subjected to autologous PRP instillation under Ultrasound
Guidance, and Hysteroscopic guided PRP. After PRP, a significant output was obtained, with improved
Anti Mullerian Hormone (AMH) and Antral Follicle Count (AFC) and out of five
women three women conceived by Intra Cytoplasmic Sperm Injection (ICSI). PRP
injected in women with Poor Ovarian Response found successful ovarian
rejuvenation within 1 - 3 months and had a 60% of pregnancy rate, PRP into
the endometrium had 53.8% successful pregnancies. We have not encountered any
complications.