TITLE:
Overview of an Emerging Coronavirus Infection, COVID-19: Current Status of Vaccine Development and Therapeutics
AUTHORS:
Md. Sohel Rana, Md. Maruf Hasan, Md. Eshak Enan, Fatema-Tuz Zohora, A. T. M. Zafrul Azam
KEYWORDS:
COVID-19, Epidemiology, Therapeutic, Vaccine, S Protein
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.12 No.1,
January
29,
2021
ABSTRACT: Coronavirus
infectious disease 2019 (COVID-19) first reported in Wuhan, China, causes serious
respiratory illnesses such as lung failure and pneumonia. Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) the pathogenic agent of COVID-19 has been confirmed as a novel coronavirus.
WHO announced COVID-19 a global pandemic and now the whole world is eagerly waiting for vaccines and therapeutic treatment to get
rid of this unstoppable coronavirus. As COVID-19 infection, a global threat creates
unwanted human casualties and serious economic loss. To stop the ongoing uncontrolled
situation researchers are racing to develop prevention and treatment strategies.
Vaccines of different countries are in clinical and preclinical trials and the repurposed-drugs
are providing to find out a positive result against COVID-19. The report is an analysis of published information
focusing on treatment options including vaccination, drug-therapy, cytokines, therapeutic
antibodies. Most of the vaccine’s development strategies and drugs target the surface structural spike glycoprotein
or S-protein, the major inducer of pathogenic responses. Here, it is reviewed the
features of SARS-CoV-2 and the global current status of therapeutic, and vaccine development for the prevention
and effective treatment of COVID-19.