TITLE:
Vitamin D and Its Association with Glycemic Status in Bangladeshi Adults with Newly Detected Type 2 Diabetes Mellitus
AUTHORS:
Md. Firoj Hossain, Tahniyah Haq, Md. Fariduddin, Shahjada Selim, M. A. Hasanat, Md. Shahed-Morshed
KEYWORDS:
Vitamin D, Type 2 Diabetes Mellitus, Vitamin D Deficiency, Glycated Hemoglobin A1c
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.11 No.1,
January
18,
2021
ABSTRACT: Background: Very limited data are available regarding the association of vitamin D with glycemic status among adults with newly detected type 2 diabetes mellitus (T2DM) in Bangladesh. Objectives: To determine vitamin D status and its association with glycemic status in Bangladeshi adults with newly detected T2DM. Materials and Methods: This cross-sectional study was carried out in 102 newly detected T2DM diagnosed on the basis of the American Diabetes Association 2017 criteria (age: 42.95 ± 10.68 yrs.; m/f: 44/58) and equal number of age and sex matched controls (age: 40.43 ± 11.04 years) recruited consecutively from the Department of Endocrinology, BSMMU to measure serum vitamin D by high performance liquid chromatography method. Results: Both vitamin D deficiency (p p p 1c (r = -0.249, p = 0.011) in patients with T2DM. HbA1c was linearly associated with vitamin D (β = -0.26, p = 0.009) and severe vitamin D deficiency by binary (OR = 1.37, p = 0.003) and multinomial logistic regression (HbA1c ≥ 10%: OR = 4.25, p = 0.04) in people with T2DM after adjustment for age and BMI. Conclusions: Severe vitamin D deficiency was positively associated with T2DM and inversely associated with HbA1c in patients with newly detected T2DM.