TITLE:
Research on HOXA11-AS in Malignant Tumors
AUTHORS:
Juncheng Guo, Jinfang Zheng, Yijun Yang
KEYWORDS:
Long Non-Coding RNA, HOXA11-AS, Malignant Tumor
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.12 No.1,
January
14,
2021
ABSTRACT: Long-chain non-coding RNA HOXA11 antisense RNA
(HOXA11-AS) is a kind of lncRNA discovered in recent years. Long-chain non-coding RNA (LncRNA) is
an important regulatory factor of protein-coding genes, especially the
disorder of LncRNA in more and more diseases which are found, including cancer. HOXA11-AS was first
discovered in mouse embryo cDNA library using
probes, and then it was discovered by scholars and played an important
role in human cervical cancer, gastric cancer, glioma and other malignant tumor
cells. Overexpression of HOXA11-AS has been found to promote cell proliferation, migration and
tumor invasion, and has a carcinogenic effect. HOXA11-AS can promote tumor proliferation, metastasis and
other malignant biological behaviors by interacting with miRNA and EZH2 protein, and is considered to be carcinogenic lncRNA. The discovery of HOXA11-AS provides new ideas for tumor prevention
and treatment.