Pulimood, T.B. and Park, G.R. (2000) Debate: Albumin administration should be avoided in the critically ill. Critical Care, 4, 151-155. Also available: http://ccforum/ content/4/3/151
has been cited by the following article:
TITLE: Protein phase instability developed in plasma of sick patients: clinical observations and model experiments
AUTHORS: Tatiana Yakhno
KEYWORDS: Protein Aggregation in Serum; Mechanisms of Inflammation
JOURNAL NAME: Natural Science, Vol.2 No.3, April 12, 2010
ABSTRACT: This article discusses the causes of formation of micron-size protein structures in liquid plasma or serum of the patients with different diseases, which are accompanied by inflammatory reac-tions. Self-organizing processes in sessile dry-ing drops of natural and model biological liq-uids are used for study of possible mechanisms of development the protein phase instability in serum. There was shown that violation of opti-mal ratio between albumin and osmotic active components could lead to loss of albumin ag-gregative stability and albumin coagulation structures formation. Possible role of these structures in pathogenesis of inflammation is discussed.