TITLE:
Psoriasis: A Comprehensive Review on the Aetiopathogenesis and Recent Advances in Long-Term Management of Patients with Plaque Psoriasis
AUTHORS:
Tanja Gmeiner, Jasna Grzelj, Borut Strukelj, Luka Stopar, Pij Bogomir Marko
KEYWORDS:
Biologicals, Psoriasis, Pharmacotherapy, Dermatology
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.11 No.12,
December
31,
2020
ABSTRACT: Immense changes have been introduced in psoriasis
treatment, including successful
systemic treatment of inflammation and education of psoriatic patients.
The focus of this review is the latest developments in the understanding of the aetiopathogenesis of
psoriasis, the significance of its comorbidities, treatment possibilities and
long-term management using the latest insight provided by pharmacogenetics and
identification of biomarkers. The successful control of the disease leads to
reduction of myocardial infarction and long-term cardiovascular risk but is
usually achieved after various therapeutic attempts until the best-matched
treatment for the individual is identified. There is a high unmet medical need
for revealing biomarkers associated with disease prognosis, comorbidities,
response to therapy and adverse effects. More studies have to be performed for
identification and validation of biomarkers and implementation of personalized
medicine into clinical practice.