TITLE:
Protein phase instability developed in plasma of sick patients: clinical observations and model experiments
AUTHORS:
Tatiana Yakhno
KEYWORDS:
Protein Aggregation in Serum; Mechanisms of Inflammation
JOURNAL NAME:
Natural Science,
Vol.2 No.3,
April
12,
2010
ABSTRACT: This article discusses the causes of formation of micron-size protein structures in liquid plasma or serum of the patients with different diseases, which are accompanied by inflammatory reac-tions. Self-organizing processes in sessile dry-ing drops of natural and model biological liq-uids are used for study of possible mechanisms of development the protein phase instability in serum. There was shown that violation of opti-mal ratio between albumin and osmotic active components could lead to loss of albumin ag-gregative stability and albumin coagulation structures formation. Possible role of these structures in pathogenesis of inflammation is discussed.