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Green, M.A., Noguchi, C.T., Keydan, A.J., Marwah, S.S. and Stuart, J. (1998) Polymerization of sickle cell hem- oglobin at arterial oxygen saturation impairs erythrocyte deformability. Journal of Clinical Investigation, 81, 1669-1674.

has been cited by the following article:

• TITLE: Protein phase instability developed in plasma of sick patients: clinical observations and model experiments

  AUTHORS: Tatiana Yakhno

  KEYWORDS: Protein Aggregation in Serum; Mechanisms of Inflammation

  JOURNAL NAME: Natural Science, Vol.2 No.3, April 12, 2010

  ABSTRACT: This article discusses the causes of formation of micron-size protein structures in liquid plasma or serum of the patients with different diseases, which are accompanied by inflammatory reac-tions. Self-organizing processes in sessile dry-ing drops of natural and model biological liq-uids are used for study of possible mechanisms of development the protein phase instability in serum. There was shown that violation of opti-mal ratio between albumin and osmotic active components could lead to loss of albumin ag-gregative stability and albumin coagulation structures formation. Possible role of these structures in pathogenesis of inflammation is discussed.