TITLE:
Effects of Lidocaine Infusion on Quality of Recovery and Agitation after Functional Endoscopic Sinus Surgery: Randomized Controlled Study
AUTHORS:
Rehab Abd Elraof Abd Elaziz, Shahenda Shaban, Shaker Abd Elaziz
KEYWORDS:
Lidocaine, Quality of Recovery-40 Questionnaire, Emergence Agitation, FEES
JOURNAL NAME:
Open Journal of Anesthesiology,
Vol.10 No.12,
December
29,
2020
ABSTRACT: Background: After functional endoscopic nasal surgery, emergence agitation is not uncommon. The aim of this trial was to investigate the effect of perioperative lidocaine infusion on postoperative early recovery quality and incidence of emergence agitation in patient undergoing functional endoscopic sinus surgery.Study Design:Prospective, randomized, double-blinded, placebo-controlled trial.Methods: 100 patients of ASA I and II, aged 18-50 years, of both sexes scheduled for FEES, were assigned into two groups. In Group L; patients received an intravenous bolus infusion of 1.5mg/kg lidocaine just before induction of anesthesia followed by a continuous infusion of 2mg/kg/h during the operation and until the end of the surgery. In Group C; patients received normal saline infusion with the same volume as group L according to the same protocol. The primary endpoints were incidence of emergence agitationand postoperative recovery quality (QoR-40) score on first postoperative day (POD1).Results:Incidence of emergence agitation wassignificantly lower in group L (P0.05) compared with group C. Global QoR-40 scores on POD1 weresignificantly lower in both groups compared with preoperative assessment, it was significantly higher in group L on POD1 (P0.05) than in group C. Among the five dimensions of QoR-40, the scores for physical comfort and pain were superior in group L compared to group C (P0.05) at POD1.Conclusion: Systemic lidocaine infusion can improve QoR-40 scores and decrease incidence of emergence agitation in patients scheduledfor FEES,also it reducesthe duration of stay in PACU after surgery.