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Han, S.W., Yang, X., Qi, Q., Pan, Y.F., Chen, Y.C., Shen, J.J., Liao, H.H. and Ji, Z.N. (2016) Potential Screening and Early Diagnosis Method for Cancer: Tongue Diagnosis. International Journal of Oncology, 48, 2257-2264.
https://doi.org/10.3892/ijo.2016.3466

has been cited by the following article:

• TITLE: Study on Tongue Coating Microbiota in Patients with Atrophic Gastritis

  AUTHORS: Lingshan Bao, Yingcong Yu

  KEYWORDS: Atrophic Gastritis, Tongue Coating Microbiota, 16S rRNA Sequencing

  JOURNAL NAME: Advances in Microbiology, Vol.10 No.12, December 28, 2020

  ABSTRACT: Aims: To explore the tongue coating microbiota composition in patients with atrophic gastritis by using the 16S rRNA gene sequencing technology. Methods: The study included 29 atrophic gastritis patients and 29 age and gender-matched non-atrophic gastritis controls. By sequencing the V3-V4 region of the 16S rRNA, we investigated the microbial community structure and diversity on the tongue coating. Results: There was no significant difference in the microbial diversity on the tongue coating between the two groups. However, compared with the control, the atrophic gastritis group had a smaller number of operational taxonomic units (OTUs). At the class level, patients with atrophic gastritis had lower relative abundances of Betaproteobacteria and Spirochaetia than the control group. At the gene level, the abundance of Neisseria and Aggregatibacter in atrophic gastritis group had significantly decreased compared with control ones. Furthermore, functional prediction revealed that 24 metabolic pathways significantly differed between the two groups. Conclusions: Our findings provide novel evidence that tongue coating microbiota may be a biomarker for characterizing patient with atrophic gastritis, but its mechanism needs to be further elaborated.