TITLE:
Ultrasound Promoted Synthesis and Antimicrobial Evaluation of Novel Seven and Eight-Membered 1,3-Disubstituted Cyclic Amidinium Salts
AUTHORS:
María M. Blanco, María A. Reamírez, María C. Caterina, Isabel A. Perillo, Guido A. Oppezzo, María S. Shmidt, Gabriel O. Gutkind, José Di Conza, Alejandra Salerno
KEYWORDS:
Medium Ring Amidinium Salts, Ultrasonic Assisted Synthesis, Antimicrobial, Green Chemistry
JOURNAL NAME:
Open Journal of Medicinal Chemistry,
Vol.10 No.4,
December
28,
2020
ABSTRACT: Series of 1,3-dibenzyl-1H-4,5,6,7-tetrahydro-1,3-diazepinium
and 1,4,5,6,7,8-hexahydro-1,3-diazocinium salts derivatives were efficiently
synthesized in excellent yields by dehydrogenation of the corresponding N,N'-dibenzyl aminals employing N-bromosuccinimide
(NBS) as dehydrogenating agent under ultrasound irradiation. The present
methodology has proven to be simple, efficient and environmentally benign. All
novel compounds were identified and characterized by 1H and 13C
NMR spectra. The synthesized compounds were screened for their antimicrobial
activities.