TITLE:
Complete Genome Sequence of Bacillus thuringiensis Serovar coreanensis ST7 with Toxicity to Human Cancer Cells
AUTHORS:
Jing Zhang, Yiping Liu, Rui Liu, Xu Liu, Baoli Zhang, Jun Zhu
KEYWORDS:
Bacillus thuringiensis Serovar Coreanensis ST7, Gapless Chromosome, Plasmid Sequences, Genomic Feature, Cluster of Orthologous Groups of Proteins
JOURNAL NAME:
Advances in Microbiology,
Vol.10 No.12,
December
23,
2020
ABSTRACT: Bacillus thuringiensis (Bt) parasporal crystal proteins were well known to be toxic to certain insects and cytocidal activity against various human cancer cells. Bt serovar coreanensis ST7, non-pathogenic to insects and non-hemolytic, has an important parasporin, PS4Aa1 (Cry45Aa1), with potential toxicity to human cancer cells. In this study, we reported the feature of complete genome sequence and the cluster of orthologous groups of proteins function classification of ST7. Meanwhile, the evolutionary of ST7 was also studied. The genome data of ST7 will strongly contribute to a better understanding of the genomic diversity and evolution, and enrich the Bt genome database.