TITLE:
Self-Assembly of Amyloid-Beta and Its Piezoelectric Properties
AUTHORS:
Ivonne Rosales, Laura Salazar, Daniel Luna, Alicia Negrón, Igor Bdikin, Brian J. Rodriguez, Alejandro Heredia
KEYWORDS:
Amyloid, Neurodegenerative Disorders, Self-Assembly, Piezoelectricity
JOURNAL NAME:
American Journal of Molecular Biology,
Vol.11 No.1,
December
18,
2020
ABSTRACT: Investigating amyloid nanofibril self-assembly, with an emphasis on the electromechanical property of amyloid peptides, namely, piezoelectricity, may have several important implications: 1) the self-assembly process can hinder the biological stability and give rise to the formation of amyloid structures associated with neurodegenerative diseases; 2) investigations in this field may lead to an improved understanding of high-performance, functional biological nanomaterials, 3) new technologies could be established based on peptide self-assembly and the resultant functional properties, e.g., in the creation of a piezoelectric device formed with vertical diphenylalanine peptide tubes as a piezoelectric biosensor, and 4) new knowledge can be generated about neurodegenerative disorders, potentially yielding new therapies. Therefore, in this review, we will present the current investigations associated with self-assembly of amyloid-beta, the mechanisms that generate new structures, as well as theoretical calculations exploring the functionality of the structures under physiological pressure and electric field.