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K. Yamanouchi, H. Zhou, N. Roy-Chowdhury, F. Macaluso, L. Liu, T. Yamamoto, G. R. Yannam, C. Enke, T. D. Solberg, A. B. Adelson, J. L. Platt, I. J. Fox, J. Roy-Chowdhury and C. Guha, “Hepatic Irradiation Augments Engraftment of Donor Cells Following Hepatocyte Transplantation,” Hepatology, Vol. 49, No. 1, 2009, pp. 258-267. doi:10.1002/hep.22573

has been cited by the following article:

• TITLE: Long-Term Treatment with a Compound Polysaccharide-Based Health Product (Infinitus Polysac Plus) Enhances Innate and Adaptive Immunity in Mice

  AUTHORS: Hoi-Yan Leung, Chung-Wah Ma, Qing Tao Tang, Kam-Ming Ko

  KEYWORDS: Compound Polysaccharide, Innate Immunity, Adaptive Immunity

  JOURNAL NAME: Chinese Medicine, Vol.2 No.4, December 9, 2011

  ABSTRACT: This study aimed to investigate the effects of a compound polysaccharide-based health product (Infinitus Polysac Plus, IPP) on innate and adaptive immunity in mice. Both ex vivo/in vivo mouse models and an in vitro system using cultured mouse splenocytes were adopted for the assessment of innate and adaptive immunity. For the innate immune response, long-term IPP treatment (0.26 and 0.78 g/kg * 20 doses) enhanced the carbon clearance activity and phagocytic rate of macrophages, as well as natural killer cell activity in mice. The IPP-induced increase in natural killer cell activity was accompanied by the suppression of tumor growth in Sarcoma-180 cell-inoculated mice. For the adaptive immune response, while long-term IPP treatment increased the splenocyte index in mice, IPP incubation with mouse splenocytes in vitro potentiated their concanavalin A-stimulated proliferation. Long-term IPP treatment significantly restored the hemolytic activity of serum on sheep red blood cells and dinitrofluorobenezene-induced delayed-type hypersensitivity in sensitized and immunosuppressed mice. In conclusion, the results indicate that long-term IPP treatment produces stimulatory effects on both innate and adaptive immunity in mice.